Developing a toolkit to wire synthetic transcriptional circuits in Drosophila melanogaster
The genomic control of development is done by gene regulatory networks (GRNs), these are networks of interacting transcription factors that control spatial and temporal gene expression, giving accurate instructions for the proper development of an organism. Deciphering GRNs has attracted a lot of interest and many methods have been introduced for their statistical inference from gene expression data. Recently, scientists have been offered a new way to study GRNs thanks to synthetic biology where they can test the previously established mechanistic models by reconstruction. In Synflylab we are developing a toolkit to allow the reconstruction of such networks in the powerful genetic model organism, the fruit fly.
ESADSE Saint-Etienne - Ecole d'art et de design de Saint-Etienne en partenariat avec le CRI