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CANCEL
Open for everyone
phd
- 19:00 CRI, Learning Center Extension

IT seminar – Cancer-associated fibroblasts contractility and ECM organization in tumor resistance to chemoradiotherapy

IT seminar – Cancer-associated fibroblasts contractility and ECM organization in tumor resistance to chemoradiotherapy

Speaker: Olivier Zajac

Abstract:

Patients with locally advanced rectal cancer are treated with preoperative chemoradiotherapy (CRT) followed by surgery. About 40% of patients show weak or no response to CRT. If identified early, these CRT-refractive patients could benefit from immediate surgical treatment. Thus, it is crucial to identify markers that could predict treatment response. We propose a multi-disciplinary approach that combines cancer cell biology, biophysics, and bioinformatics using patients’ material aiming to determine if physical properties of tumor microenvironnment can induce tumor resistance.