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Open for everyone
phd
- 18:30 CRI, Learning Center Extension

IT seminar – Multidisciplinary approach to treat nicotine dependence. Is it enough?

IT seminar – Multidisciplinary approach to treat nicotine dependence. Is it enough?

Speaker: Mariana Gonzalez Medina

Abstract:

Tobacco use causes 8 million deaths every year. Nicotine is distilled from tobacco smoke and binds to nicotinic receptors (nAChRs), this promotes the release of dopamine and stimulates the brain’s reward system causing addiction.

nAChRs with a4ß2a5 subunits are associated to smoking addiction due to a single-nucleotide polymorphism on the a5 subunit which generates a loss of function. It is expected that activating a4ß2a5 could be a treatment for smoking dependence.

Studying a4ß2a5 is a complex endeavor, since there are no ligands or crystallographic structures reported. This project integrates biochemical, electrophysiological and structural data with in silico modeling, to design a4ß2a5 activators.