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Open for everyone
phd
- 18:30 CRI, Learning center extension

IT seminar – Interplay between DNA methylation and polycomb marks in maternal epigenetic inheritance

IT seminar – Interplay between DNA methylation and polycomb marks in maternal epigenetic inheritance

Speaker: Lorraine Bonneville

Abstract:

At the time of fertilization, the sperm and the oocyte carry the genetic material encoded in the DNA but also another form of information that is not genetically encoded and broadly defined as epigenetic. Whether parental epigenetic information can influence the phenotypes of the progeny is a subject of intense interest. In mammals, the epigenetic patterns that are inherited from parental gametes are massively erased after fertilization. However, two epigenetic marks -DNA methylation and trimethylation of histone H3 lysine 27 (H3K27me3)- have been shown to exhibit intergenerational heritability upon transmission by the oocyte. For my PhD project, I propose to investigate how the interplay between DNA methylation and H3K27me3 shapes the epigenetic heritage transmitted by the oocyte and how they influence the embryonic transcriptome.


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