This event has ended.
CANCEL
Open for everyone
research
- 12:30 CRI

CRI Research Collaboratory seminar - Radoslaw Ejsmont

CRI Research Collaboratory seminar - Radoslaw Ejsmont

Synthetic Fly Lab - bringing SynBio to the fruitfly world

Radoslaw Ejsmont - CRI Research Fellow

Drosophila melanogaster, a popular model organism to study animal development currently lacks a comprehensive set of synthetic biology tools. Such a toolkit would enable in vivo modeling of biological pathways that control developmental processes. I will present projects, currently running in my team, that address these issues. We are working on a synthetic transcription factor framework, based on TAL effectors and a variety of activation and repression domains. We will use these factors to recapitulate gene regulatory motifs that commonly occur in developmental gene regulatory networks as well as create computation units that perform basic logical binary operations. The synthetic transcription factor framework will enable in vivo modeling of gene regulatory circuits that control cell differentiation and other developmental processes. To elucidate which members of developmental networks are essential for their function, we are developing a massively-parallel CRISPR-based synthetic rescue screen strategy. To enable the integration of synthetic transcription factors with the host pathways, we are working on strategies for the replacement of native transcription factors with their synthetic counterparts and for simultaneous insertion of multiple synthetic transcription factor binding sites upstream of the host target genes. Finally, we are using metabolic engineering to create new evolvable and selectable traits. We will use these tools to study two developmental events in Drosophila: the specification of photoreceptor neurons in the retina and the establishment of segmentation patterns in embryo development.


Upcoming events...

Divers lieux

La Semaine du Son de l'UNESCO

La Semaine du Son de l'UNESCO

CRI

Candidature Licence Frontières du Vivant

Candidature Licence Frontières du Vivant

Moulinot Compost & Biogaz

Visit the preprocessing center of the organic waste company Moulinot

Visit the preprocessing center of the organic waste company Moulinot

CRI

Mindfulness, interdisciplinary, and education research group in health : meeting 3

Mindfulness, interdisciplinary, and education research group in health : meeting 3

CRI

Sciences in Context: Metacognition and the value of information in decision making

Sciences in Context: Metacognition and the value of information in decision making

UNESCO Headquarters

International Day of Education and launch of #LEARNINGPLANET

International Day of Education and launch of #LEARNINGPLANET

Le CRI

EDU GAME JAM III

EDU GAME JAM III

Grand Palais

ChangeNOW 2020 - The World Expo of Innovations for the Planet

ChangeNOW 2020 - The World Expo of Innovations for the Planet

Au CRI - Salle 3:11

Rencontre du Critical Thinking Club #3

Rencontre du Critical Thinking Club #3

CRI - amphiteatre

intérêt de la recherche qualitative en santé: explorer ce que les patients, les aidants, les soignants vivent.

intérêt de la recherche qualitative en santé: explorer ce que les patients, les aidants, les soignants vivent.

CRI

Workshop: Designing your Life (2-parts)

Workshop: Designing your Life (2-parts)

CRI

place de la méditation de pleine conscience en cancérologie: pour les patients et les soignants

place de la méditation de pleine conscience en cancérologie: pour les patients et les soignants

CRI

Microbiote et alimentation: de la science à nos assiettes

Microbiote et alimentation: de la science à nos assiettes

CRI

réunion d'information Méditation et étudiants en médecine - cycle MBSR printemps 2020

réunion d'information Méditation et étudiants en médecine - cycle MBSR printemps 2020

CRI Learning Center Extension

CRI Research seminar - Kirstie Whitaker – Participatory citizen science to improve autistic people's lives

CRI Research seminar - Kirstie Whitaker – Participatory citizen science to improve autistic people's lives

CRI

Rébellion contre une vieillesse aliénée - Plus de temps de vie c’est bien, plus vivant c’est encore mieux.

Rébellion contre une vieillesse aliénée - Plus de temps de vie c’est bien, plus vivant c’est encore mieux.

CRI

Lancement 7ème saison Data for Good

Lancement 7ème saison Data for Good

CRI Amphitheater

Biotech Start-up Series #1: Synthetic Biology, bringing new tools to the clinic

Biotech Start-up Series #1: Synthetic Biology, bringing new tools to the clinic

CRI

Journée Portes Ouvertes LFdV

Journée Portes Ouvertes LFdV

CRI

Combining Art and Science in medicine to explore empathy

crilogo

CRI

Les soins palliatifs pédiatriques: pas des petits adultes

Les soins palliatifs pédiatriques: pas des petits adultes

CRI

Remix ta thèse

Remix ta thèse

CRI - Learning Center Extension

CRI Research Collaboratory seminar - Gert-Jan Both

CRI Research Collaboratory seminar - Gert-Jan Both

CRI

Prendre soin : tous humains ? par Dr Marie-Aude Piot

Prendre soin : tous humains ? par Dr Marie-Aude Piot

Sorbonne Université - Campus Jussieu (exact room and building within the Jussieu Campus will be specified at a later date)

The 2ndInternational Colloquium on Network and Evolution, April 24th, Sorbonne Université, Paris France (Free but registration strongly encouraged)

crilogo

CRI

Les directives anticipées et la planification anticipée des soins par Gian Domenico Borasio

Les directives anticipées et la planification anticipée des soins par Gian Domenico Borasio

CRI

Euthanasie, suicide assisté et loi Leonetti: l’évidence scientifique par Gian Domenico Borasio

Euthanasie, suicide assisté et loi Leonetti: l’évidence scientifique par Gian Domenico Borasio