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Network Seminar - Networks & Machine Learning in Biomedical Research: from Generative Models in Social Neurosciences to Multi-Scale Priors in Precision Medicine

Thu 23 May 17:00 PM - 18:00 PM @ CRI, Learning Center extension

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Network Seminar - Networks & Machine Learning in Biomedical Research: from Generative Models in Social Neurosciences to Multi-Scale Priors in Precision Medicine

We are happy to invite you to the next network seminar at CRI! We will welcome Guillaume Dumas from Pasteur Institute who will talk about networks in social neurosciences. It will be in the Learning Center extension (room 0.06) at the CRI.

Title: Networks & Machine Learning in Biomedical Research: from Generative Models in Social Neurosciences to Multi-Scale Priors in Precision Medicine

Abstract: With the recent development of –omics fields, multiple sub-disciplines in life sciences have embraced networks as a valuable formalism. This presentation will present two projects illustrating how –omics networks can be used in biomedical research: 1) whole brain neuro-computational modelling with Connectomics, and 2) network-based stratification (NBS) with Genomics. The first example builds on the importance of anatomical and functional interactions in neuroscience; through modelling, numerical simulation provides insight into the basic mechanisms that enable integrative neural processes and how structural brain networks generate spatially and temporally organised brain activity at both intra- and inter-individual levels. The second example was originally designed for cancer research; the NBS combines genetic mutation profiles of patients with protein-protein interaction (PPI) networks to uncover clusters of patients with similar tumour subtypes. Here we will review the original results through a case study of reproducibility in bioinformatics and then explain the challenges to apply it to autism.

Bio: Guillaume Dumas is a researcher in the department of neuroscience of the Institut Pasteur in Paris. Originally from engineering and theoretical physics, he did a Ph.D. on cognitive neuroscience at the University of Paris 6 (UPMC) and then moved in a postdoc at the Center for Complex System and Brain Science of Florida Atlantic University. He came back to France for working in the “Human Genetics and Cognitive Functions” unit of the Institut Pasteur, where he started as a postdoc before receiving his permanent position. He then created the platform SoNeTAA (Social Neuroscience for Therapeutic Approaches of Autism) at the child and adolescent psychiatric department of the Robert Debré hospital in Paris. His interdisciplinary research is focused on integrative accounts of neural, behavioural and social coordination dynamics. Methods used range from both intra- and inter-individual neuroimaging techniques to neurocomputational simulations. He is also a science writer and journalist and is engaged with multiple projects at the cross-road of Art and Science. He has, for instance, co-founded HackYourPhD, a community advocating internationally the use of openness in Science and Knowledge as a common good, and ALIUS, an international and interdisciplinary research group dedicated to the investigation of the diversity of consciousness.

Co-organized by CRI fellows Liubov Tupikina and Marc Santolini