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IT seminar: Role of Greb1l in left-right asymmetric heart morphogenesis and congenital heart defects

Thu 18 Apr 18:00 PM - 18:30 PM @ CRI Lounge

IT seminar: Role of Greb1l in left-right asymmetric heart morphogenesis and congenital heart defects

Speaker: Segolène Bernheim

Abstract:

Establishment of a left-right asymmetry is essential for the function of the heart, which is to ensure a double blood circulation. This asymmetry is initiated during an embryonic process, in which the heart tube acquires a loop shape. The molecular cascade at the origin of left-right asymmetry is well established and involved in the severe heart defects of the heterotaxy syndrome. However, another 20% of heart malformations display cardiac chamber misalignment and their origin is poorly understood. With an available novel mouse model, inactivated for Greb1l, and expertise on the morphogenesis of the cardiac loop, we want to provide novel insight into malformations displaying an abnormal, super-inferior, alignment of the ventricles. We will test the hypothesis that this defect results from a problem of antero-posterior patterning of cardiac progenitors, involving retinoic acid signaling, and impacting the shape of the embryonic heart loop.